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Systemic lupus erythematosus
Core of basic research: Decipher the mechanisms of autoantibody (ANA, dsDNA antibody) production and immune complex deposition, explore the molecular basis of excessive B cell activation and Treg cell dysfunction, as well as the impact of IFN-α-dominated "interferon signature" on multi-organ damage.
Core key proteins: ANA/dsDNA antibodies (autoantibodies forming immune complexes), Complement C3/C4 (immune complexes activate complement leading to tissue damage), TNF-α/IL-6/IFN-α (pro-inflammatory cytokines), STAT1 (mediates IFN-α signaling), NF-κB (drives inflammation and autoantibody production), B cells/Treg cells (core of immune imbalance).
Core key proteins: ANA/dsDNA antibodies (autoantibodies forming immune complexes), Complement C3/C4 (immune complexes activate complement leading to tissue damage), TNF-α/IL-6/IFN-α (pro-inflammatory cytokines), STAT1 (mediates IFN-α signaling), NF-κB (drives inflammation and autoantibody production), B cells/Treg cells (core of immune imbalance).
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