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Pathway and Functional Annotation Databases

Integrate information on gene functions, metabolic pathways, and biological process annotations, facilitating gene function classification, pathway enrichment, and mechanism research.
    Database Name
    Core Function
    Official Website
  • KEGG
    Integrates information on interactions between genes, proteins, metabolites, and pathways, providing metabolic pathway and signaling pathway analysis functions
    https://www.kegg.jp/
  • GO (Gene Ontology)
    Provides standardized gene function terms, divided into three categories: Molecular Function, Cellular Component, and Biological Process, for functional annotation
    https://www.geneontology.org/
  • Reactome
    A pathway database centered on biological processes, presenting reaction pathways and regulatory relationships between biomolecules
    https://reactome.org/
  • DO (Disease Ontology)
    A standardized disease terminology system that links diseases with gene and phenotype data, supporting disease mechanism association analysis
    https://disease-ontology.org/

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