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Autoimmune thyroid disease
Core of basic research: Decipher the abnormal recognition mechanism of thyroid antigens (TSHR, TPO, Tg) by the immune system, explore the synergistic pathogenic effects of CD4+ T cell subsets (Th1/Th17) and autoantibodies, as well as the interaction between genetic factors (HLA-II) and environmental factors.
Core key proteins: TSHR (thyroid-stimulating hormone receptor, target of autoantibodies), TPO (thyroid peroxidase, target of autoantibodies), Tg (thyroglobulin, target of autoantibodies), IFN-γ/TNF-α/IL-6 (pro-inflammatory cytokines), CD4+ T cells/B cells (produce autoantibodies), MHC-II (presents thyroid antigens).
Core key proteins: TSHR (thyroid-stimulating hormone receptor, target of autoantibodies), TPO (thyroid peroxidase, target of autoantibodies), Tg (thyroglobulin, target of autoantibodies), IFN-γ/TNF-α/IL-6 (pro-inflammatory cytokines), CD4+ T cells/B cells (produce autoantibodies), MHC-II (presents thyroid antigens).
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