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Graft-versus-host disease
Core of basic research: Decipher the activation mechanism of donor T cells after recognizing recipient tissue antigens, explore the damaging effects of Th1/Th17 cells and cytokines (TNF-α/IL-6/IL-17) on target organs such as skin, liver, and intestines, as well as molecular strategies for inducing immune tolerance.
Core key proteins: MHC-I/II (recipient antigens activating donor T cells), TCR (donor T cell receptor), CD4+/CD8+ T cells (effector cells), TNF-α/IL-6/IL-17 (pro-inflammatory cytokines), STAT3/NF-κB (signal transcription factors).
Core key proteins: MHC-I/II (recipient antigens activating donor T cells), TCR (donor T cell receptor), CD4+/CD8+ T cells (effector cells), TNF-α/IL-6/IL-17 (pro-inflammatory cytokines), STAT3/NF-κB (signal transcription factors).
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