MicroRNAs in cancer
Core of basic research: Clarify the regulatory networks of miRNAs as oncogenes or tumor suppressor genes, explore their mechanisms of regulating cell proliferation, apoptosis, and migration through targeted mRNA degradation or translational inhibition, as well as their potential value in early tumor diagnosis and prognosis evaluation.
Core key proteins (target-related): Let-7 family (tumor suppressor targeting oncogenes such as RAS), miR-17-92 cluster (oncogenic inhibiting apoptosis-related genes), miR-21 (oncogenic targeting tumor suppressor genes such as PTEN), miR-155 (oncogenic regulating immunity and inflammation), PTEN (core target of miR-21), Bcl-2 (anti-apoptotic protein, target of miR-15/16).
Core key proteins (target-related): Let-7 family (tumor suppressor targeting oncogenes such as RAS), miR-17-92 cluster (oncogenic inhibiting apoptosis-related genes), miR-21 (oncogenic targeting tumor suppressor genes such as PTEN), miR-155 (oncogenic regulating immunity and inflammation), PTEN (core target of miR-21), Bcl-2 (anti-apoptotic protein, target of miR-15/16).
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