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Renal cell carcinoma
Core of basic research: Centered on VHL gene inactivation, decipher the abnormal hypoxia adaptation and angiogenesis caused by HIF-1α stabilization, explore the abnormal activation of receptor tyrosine kinases such as MET and EGFR, as well as the role of immune checkpoints (PD-L1/CTLA-4) in clear cell carcinoma.
Core key proteins: VHL (tumor suppressor gene, inactivation stabilizes HIF-1α), HIF-1α (hypoxia-inducible factor regulating angiogenesis-related genes), VEGF/PDGF (angiogenic and proliferation factors), mTOR/Akt (signaling pathway regulating growth), MET (receptor tyrosine kinase promoting invasion), PD-L1/CTLA-4 (immune escape), EGFR (enhances proliferation signals).
Core key proteins: VHL (tumor suppressor gene, inactivation stabilizes HIF-1α), HIF-1α (hypoxia-inducible factor regulating angiogenesis-related genes), VEGF/PDGF (angiogenic and proliferation factors), mTOR/Akt (signaling pathway regulating growth), MET (receptor tyrosine kinase promoting invasion), PD-L1/CTLA-4 (immune escape), EGFR (enhances proliferation signals).
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