Transcriptional misregulation in cancer
Core of basic research: Clarify the abnormal expression or dysfunction of transcription factors (MYC, p53) and chromatin-modifying enzymes (HDAC, HAT), explore their role in the dysregulated transcriptional control of proliferation and apoptosis-related genes, providing targets for the development of epigenetic drugs (e.g., HDAC inhibitors).
Core key proteins: MYC (broad-spectrum oncogenic transcription factor), p53 (transcription factor regulating tumor suppressor genes), STAT3/NF-κB/AP-1 (inflammation and proliferation-related transcription factors), E2F (cell cycle-related transcription factor), HDAC (histone deacetylase inhibiting tumor suppressor genes), HAT (histone acetyltransferase activating oncogenes), SUV39H1 (histone methyltransferase regulating chromatin status).
Core key proteins: MYC (broad-spectrum oncogenic transcription factor), p53 (transcription factor regulating tumor suppressor genes), STAT3/NF-κB/AP-1 (inflammation and proliferation-related transcription factors), E2F (cell cycle-related transcription factor), HDAC (histone deacetylase inhibiting tumor suppressor genes), HAT (histone acetyltransferase activating oncogenes), SUV39H1 (histone methyltransferase regulating chromatin status).
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