Prostate cancer
Core of basic research: Focus on the androgen receptor (AR)-mediated transcriptional regulatory network, explore the impact of AR amplification/mutation on hormone dependence, and the crosstalk between the PI3K-Akt-mTOR pathway and AR signals, focusing on the castration resistance mechanism in advanced prostate cancer.
Core key proteins: AR (androgen receptor mediating hormone-dependent proliferation), PSA (prostate-specific antigen as diagnostic marker), PI3K/Akt/mTOR (signaling pathway enhancing survival and metabolism), PTEN (inactivation promotes pathway activation), TP53 (tumor suppressor gene, mutations associated with progression), MYC (transcription factor promoting proliferation), VEGF (angiogenesis).
Core key proteins: AR (androgen receptor mediating hormone-dependent proliferation), PSA (prostate-specific antigen as diagnostic marker), PI3K/Akt/mTOR (signaling pathway enhancing survival and metabolism), PTEN (inactivation promotes pathway activation), TP53 (tumor suppressor gene, mutations associated with progression), MYC (transcription factor promoting proliferation), VEGF (angiogenesis).
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